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Exocyclic DNA adducts in mutagenesis and carcinogenesis

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Published by International Agency for Research on Cancer in Lyon .
Written in English


  • Carcinogenesis -- Molecular aspects -- Congresses.,
  • DNA -- Congresses.,
  • Mutagenesis -- Congresses.

Book details:

Edition Notes

Statementedited by B. Singer and H. Bartsch.
SeriesIARC scientific publications ;, no. 150
ContributionsBartsch, H., Singer, B. 1922-, International Agency for Research on Cancer.
LC ClassificationsRC268.5 .E976 1999
The Physical Object
Paginationxvi, 361 p. :
Number of Pages361
ID Numbers
Open LibraryOL6852049M
ISBN 109283221508
LC Control Number00357873

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Exocyclic DNA adducts: Implications in mutagenesis and carcinogenesis Article (PDF Available) in Química Nova 25(5) · September with 42 Reads How we measure 'reads'. The IARC Scientific Publications aim to disseminate the results of IARC-coordinated scientific research. Topics span the range of IARC’s research scope, and the series includes the Cancer Incidence in Five Continents volumes. Print Book, PDF. Details. Exocyclic DNA Adducts in Mutagenesis and Carcinogenesis IARC Scientific Publication. Mutagenesis / m juː t ə ˈ dʒ ɛ n ɪ s ɪ s / is a process by which the genetic information of an organism is changed, resulting in a may occur spontaneously in nature, or as a result of exposure to can also be achieved experimentally using laboratory procedures. In molecular genetics, a DNA adduct is a segment of DNA bound to a cancer-causing process could be the start of a cancerous cell, or adducts in scientific experiments are used as biomarkers of exposure and as such are themselves measured to reflect quantitatively, for comparison, the amount of carcinogen exposure to the subject organism, for example rats or.

Bartsch, H., , Exocyclic adducts as new risk markers for DNA damage in man, in: Singer, B., Bartsch, H. (eds) Exocyclic DNA Adducts in Mutagenesis and Nair, J., , Lipid peroxid-induced etheno-DNA adducts in humas in: Singer,B.,Bartsch,H.,(eds)Exocyclic DNA Adducts in Mutagenesis and Carcinogenesis,IARC Sci Buy this book on Cited by: Mar 03,  · This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers. The multi-stage model of chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action will be a focal point. The balance between metabolic activation to form 2/5(2). Oct 01,  · The reason being that never before has it appeared to be so easy, or less difficult, to entertain the question. Hopefully this effort will spare colleagues confronting the same question some time. At the same time I will take the opportunity to describe developments in the identification of Cited by: Jul 01,  · We therefore investigated use of exocyclic (etheno) DNA adducts, which are chemically stable, secondary oxidation products. These turned out to be reliable markers of oxidative stress-derived DNA damage. A monograph summarizes the role of this type of exocyclic DNA lesions in mutagenesis and carcinogenesis (Singer and Bartsch, ).Cited by:

This paper utilizes 30 years of research on three "known human carcinogens": formaldehyde, vinyl chloride (VC), and ethylene oxide (EO), each of which forms DNA adducts identical to endogenous DNA adducts in all individuals. It outlines quantitative data on endogenous adducts, mutagenicity, and relationships between endogenous and exogenous Cited by: Sep 10,  · Mechanisms of mutagenesis by exocyclic DNA adducts. Transfection of M13 viral DNA bearing a site-specific adduct shows that ethenocytosine is a highly efficient RecA-independent mutagenic noninstructional lesion. Palejwala VA(1), Simha D, Humayun by: In Exocyclic DNA Adducts in Mutagenesis and Carcinogenesis (eds. Singer B., Bartsch H.) IARC Sci. Publ. Bartsch H. (eds.) The Role of Cyclic Nucleic Acid Adducts in Carcinogenesis and Mutagenesis, IARC, Scientific Publication, 70, IARC, Lyon, France () Google Buy this book on publisher's site; Reprints and Permissions; Personalised Author: John C. Stavridis. Role of DNA Adducts in Carcinogenesis. occurrence and possible role of ε-DNA adducts in carcinogenesis and mutagenesis. A number of promutagenic exocyclic .